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yhdA [2018-02-11T19:25:46.000Z]
similar to NADPH-dependent azobenzene FMN reductase
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]Gene
Coordinates
1,010,445 → 1,010,969
The protein
Protein family
azoreductase type 2 family (according to Swiss-Prot)Paralogous protein(s)
[protein|CAFAE305B1771DD89E81F75A6713161393BE99A0|PgcM] (31%)[SW|Cofactors]
FMN [Pubmed|16752898]Structure
[PDB|3GFQ] (99% identity),[PDB|1NNI]Expression and Regulation
Operons
genes
[gene|8D570AEE5D78A9A3CDBB1F457630BAF5DB59BCFD|yhcY]-[gene|DD799ED3EB79457C27ED30C7B4DBBC2C8F962191|yhcZ]-[gene|345EC248C0ADF48B0C25B175241AAE982E0E9B78|yhdA]
description
[Pubmed|16816187]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|16816187], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|49E70A20CC05DBE485953C0AE34E634EFB33C3B2|LiaR]: activation, [Pubmed|16816187], in [regulon|49E70A20CC05DBE485953C0AE34E634EFB33C3B2|LiaR regulon]view in new tabBiological materials
Mutant
MGNA-A689 (yhdA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/689 NBRP B. subtilis, Japan]BKE09340 (Δ[gene|345EC248C0ADF48B0C25B175241AAE982E0E9B78|yhdA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE09340 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGTGCCATTTATGACTAACA, downstream forward: _UP4_GGCGTCTAAACGCCGGGATTBKK09340 (Δ[gene|345EC248C0ADF48B0C25B175241AAE982E0E9B78|yhdA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK09340 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGTGCCATTTATGACTAACA, downstream forward: _UP4_GGCGTCTAAACGCCGGGATTReferences
16816187,16752898,20639339,20640807